The Digital Optical Chemistry System (DOC)

Critical to the understanding of cancer, a disease involving the complex interplay of a large set of genes, is the thorough analysis of cancer and normal tissues using state-of-the-art data gathering technologies.  One such technology, our Digital Optical Chemistry custom microarray manufacturing system was developed and perfected in the last few years.  This technology enables us to acquire sequence variants, expression profiles, methylation/DNA packing profiles, splice variants, array CGH profiles and DNA/Protein interactions and then integrate this data computationally to develop signatures and interpretations of cancer.  The flexibility of the DOC instrument and its associated software has enabled us to produce custom chips for sequence-available genomes for analysis of expression or sequence variation.  Of particular value has been our ability to rapidly produce chips for the analysis of emerging pathogens and biothreat agents.