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Project: UBDA: Universal Bio-signature Detection Array Champion: Jenni Weeks We have developed a custom sequence-independent microarray designed to serve as a universal detection system for biological warfare threats and pathogens that may affect humans and agriculture. The overall goal is to produce a field deployable microarray that is universal and capable of distinguishing all potential bio-weapon infectious agents and naturally occuring and evolving pathogens. Every pathogen contains a unique genome which in turn will produce a unique bio-signature when hybridized to the array. By comparing an unknown bio-signature to our database of known bio-signatures, we will potential by able to identify any potential pathogen threat, isolated or in a host.
Figure 1: Image
of UBDA hybridized with human genomic DNA
Figure 2: Scatter plot of UBDA signal intensities. Raw signals were corrected for background, and probe ids 1-32000 (out of 385K) were plotted to examine the dynamic range at the indicated scanning intensities Related Publications Organism identification
using a genome sequence-independent universal microarray probe set. |
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