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Project: Gene Expression Microarray Analysis and Interpretation Champion: Cristi Galindo In addition to utilizing our own custom arrays to examine the roles of microsatellites in speciation, cancer, and other human disease conditions, we also serve as the bioinformatics core for the Western Regional Center of Excellence (WRCE) for Biodefense and Emerging Infectious Diseases. Additionally, we have several collaborative relationships with laboratories at UTSW and other research institutes, including the University of Texas Medical Branch in Galveston and Texas A&M. We assist these researchers in experimental design and also perform data analysis (mainly derived from gene expression microarrays) and interpretation. Our analysis methods include the use of multiple statistical parameters in order to reduce false positives while also minimizing false negatives. Analyses are tailored to the experimental design by including biologically relevant filtering mechanisms specific to the experimental objectives. Publication-quality reports, including figures, methods, and results interpretation, are typically generated to aid the researcher in producing subsequent manuscripts. We also commonly participate in the writing and editing process itself. An example of a putative pathway is shown below:
Related Publications Murine macrophage transcriptional and functional responses to Bacillus anthracis edema toxin. Comer JE, Galindo CL, Zhang F, Wenglikowski AM, Bush KL, Garner HR, Peterson JW, Chopra AK. Microb Pathog. 2006Aug-Sep;41(2-3):96-110. Global transcriptional responses of wild-type Aeromonas hydrophila and its virulence-deficient mutant in a murine model of infection. Fadl AA, Galindo CL, Sha J, Zhang F, Garner HR, Wang HQ, Chopra AK. Microb Pathog.2007 May-Jun;42(5-6):193-203. Biological characterization of a new type III secretion system effector from a clinical isolate of Aeromonas hydrophila-part II. Sierra JC, Suarez G, Sha J, Foltz SM, Popov VL, Galindo CL, Garner HR, Chopra AK. MicrobPathog. 2007 Oct;43(4):147-60. Transcriptional
profiling of murine organ genes in response to infection with Bacillus
anthracis Ames spores. Moen ST, Yeager LA, Alteration in the activation state of new inflammation-associated targets by phospholipase A2-activating protein (PLAA). Zhang F, Sha J, Wood TG, Galindo CL, Garner HR, Burkart MF, Suarez G, Sierra JC, Agar SL, Peterson JW, Chopra AK. Cell Signal. 2008 May;20(5):844-61. Role of c-Abl kinase in DNA mismatch repair-dependent G2 cell cycle checkpoint arrest responses. Wagner MW, Li LS, Morales JC, Galindo CL, Garner HR, Bornmann WG, Boothman DA. J Biol Chem. 2008 Aug1;283(31):21382-93. An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies. Bosnakovski D, Xu Z, Gang EJ, Galindo CL, Liu M, Simsek T, Garner HR, Agha-Mohammadi S, Tassin A, CoppéeF, Belayew A, Perlingeiro RR, Kyba M. EMBO J. 2008 Oct 22;27(20):2766-79 |
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